Stage II (Dukes' B2 or B3) 
TNM T3-4, N0, M0
The cancer has spread through the muscular wall of the intestine or has extended to adjacent organs through the structures, but has not spread to lymph nodes . Dukes' B2 extends through the bowel wall; B3 involves adjacent structures.

Standard Treatment  Surgical removal of the primary tumor , with or without adjuvant chemotherapy . Specific adjuvant therapy cannot be recommended for intermediate-risk tumors outside a clinical trial. But since a significant percentage of Stage II
patients will develop recurrences,
they should be considered
candidates for clinical
trials of adjuvant
therapy.